| Mon 6-2 | Tue 6-3 | Wed 6-4 | Thu 6-5 | Fri 6-6 | Sat 6-7 | Sun 6-8 | Games | |
|---|---|---|---|---|---|---|---|---|
 |  Severino | | | |  | | | 7 |
 | @  Gallen | @ Kelly | @ Pfaadt | @  | @ | @ | 6 | |
| Strider | Sale | Holmes | @  | @ | @ | 6 | |
| @  Sugano | @ Povich | @ Eflin | @ | @ | @ | 6 | |
 |  Fitts | Bello | Giolito | @  | @ | @ | 6 | |
 |  Cannon | Smith | | Burke |  | | | 7 |
 | @  Horton | @ Boyd | @ | @ | @ | @ | 6 | |
|  Singer | Greene | Abbott | | | | 6 | |
 | @ Bibee | @ L. Ortiz | @ Cecconi |  | | | 6 | |
 | @  Márquez | @ | @ |  | | | 6 | |
| @ Flaherty | @ | @ | @ Mize | Skubal | | | 7 |
| @  McCullers Jr. | @ Gusto | @ Valdez | @ | @ | @ | 6 | |
| @  Lorenzen | @ Cameron | @ | @ | @ | @ | 6 | |
| @ Anderson | @ Kikuchi | @ Soriano | | | | 6 | |
 | May | Kershaw | Gonsolin | | @ | @ | @ | 7 |
| Meyer | Alcantara | Quantrill | @  | @ | @ | 6 | |
| @ Civale | @ Peralta | @ |  | | | 6 | |
| @ Ryan | @ López | @ Matthews | @ Ober |  | | | 7 |
| Rodón | Schmidt | Fried | | | | 6 | |
| @ Blackburn | @ Megill | @ Canning | @ Peterson | @ | @ | @ | 7 |
 | @ Sánchez | @ Abel | @ Luzardo | @ | @ | @ | 6 | |
| Skenes | Burrows | Keller | | | | 6 | |
| @ Kolek | @ Bergert | @ Pivetta | @ Cease | @ | @ | @ | 7 |
| Webb | Roupp | Harrison | Ray | | | | 7 |
| Kirby | Hancock | Woo | @ | @ | @ | 6 | |
| Pallante | Mikolas | Liberatore | | | | 6 | |
|  Rasmussen | Baz | Pepiot | | | | 6 | |
| @ Mahle | @ | @ | @ | @ | @ | 6 | |
| Francis | Berríos | Bassitt | @ | @ | @ | 6 | |
| Williams | Gore | Irvin | | | | 6 |